Hyperbaric Oxygen Therapy and Alzheimer's

Hyperbaric Oxygen Therapy and Alzheimer's

What is Hyperbaric Oxygen Therapy (HBOT)?

Hyperbaric Oxygen Therapy (HBOT) is a medical treatment that involves breathing pure oxygen in a pressurized chamber. This therapy is commonly used to treat various medical conditions, including decompression sickness, non-healing wounds, and carbon monoxide poisoning. However, recent research suggests that HBOT may also have potential benefits in the treatment of Alzheimer's dementia.

Understanding Alzheimer's Dementia

Alzheimer's dementia is a progressive neurodegenerative disease that primarily affects memory, thinking, and behavior. It is characterized by the accumulation of abnormal protein deposits in the brain, leading to the formation of plaques and tangles. These plaques and tangles disrupt the normal functioning of brain cells, causing cognitive decline and memory loss.

The Potential of HBOT in Alzheimer's Treatment

Research studies have shown promising results regarding the potential of HBOT in the treatment of Alzheimer's dementia. HBOT increases the supply of oxygen to the brain, which can help improve brain function and promote the growth of new blood vessels. Additionally, HBOT has anti-inflammatory effects and can reduce oxidative stress, both of which are believed to play a role in the development and progression of Alzheimer's disease.

Physiology of HBOT and its Effects on Alzheimer's

During HBOT, the increased pressure in the chamber allows oxygen to dissolve in the blood plasma at higher concentrations. This oxygen-rich blood can reach areas of the brain that may have reduced blood flow due to damaged blood vessels. The increased oxygen supply enhances cellular metabolism and promotes the release of growth factors, which can stimulate the repair and regeneration of brain cells.

Furthermore, HBOT has been found to reduce neuroinflammation, a process characterized by the activation of immune cells in the brain. Chronic inflammation is believed to contribute to the progression of Alzheimer's disease, and by reducing inflammation, HBOT may help slow down the neurodegenerative process.

Evidence from Clinical Studies

Several clinical studies have investigated the effects of HBOT on Alzheimer's dementia. A randomized controlled trial published in the journal Aging and Disease found that HBOT improved cognitive function and daily living activities in patients with mild to moderate Alzheimer's disease. Another study published in the Journal of Alzheimer's Disease reported that HBOT reduced brain atrophy and improved cognitive performance in patients with early-stage Alzheimer's.

Optimal Hyperbaric Pressures for Alzheimer's Disease

Currently, the optimal pressures at not known. There are several studies using pressures as mild as 1.3 ATA and others going much deeper to 2.2 ATA. In general, the Alzheimer's brain is already under stress due to the condition itself so it's often prudent to start at mild pressures and then titrate them deeper over several weeks. In addition, a full comprehensive laboratory assessment and the potential collaboration with a practitioner that can help in this regard is highly reccomended. An example here would be Dale Bredessen's trainign called RECODE. His book "The End of Alzheimer's Disease" is a compelling read as well. 

Cautious Optimism and Future Directions

While the results of these studies are promising, it is important to approach HBOT as a potential treatment for Alzheimer's dementia with cautious optimism. Further research is needed to determine the optimal treatment protocols, long-term effects, and potential side effects of HBOT in Alzheimer's patients.


1. Lin, J. W., Tsai, J. T., Lee, L. M., Lin, C. M., Hung, C. F., Hsiao, G., ... & Chen, R. M. (2018). Hyperbaric oxygen therapy improves neuroinflammation in rats with traumatic brain injury. Neurochemistry international, 117, 45-56.

2. Zhang, X., Xie, Y., Dong, H., Li, H., & Zhao, H. (2019). Hyperbaric oxygen therapy improves cognitive functioning after brain injury. Neural regeneration research, 14(3), 532.

3. Xu, X., Wang, Y., Wei, Z., Wang, Y., Zhang, X., & Zhang, X. (2020). Hyperbaric oxygen therapy improves cognitive functioning in patients with Alzheimer's disease: a systematic review and meta-analysis. Aging and disease, 11(2), 405.

Disclaimer: The information provided in this blog post is for educational purposes only and should not be considered as medical advice. Consult with a healthcare professional before considering any medical treatment.

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