HBOT and Inflammation

HBOT and Inflammation

What is inflammation?

Inflammation is a natural response of the body to injury, infection, or tissue damage. However, chronic inflammation and the cytokines that are released contribute to the development of many diseases, such as heart disease, diabetes, and cancer. 

While there are medications available to reduce inflammation, there are also natural ways to reduce inflammation. Hyperbaric Oxygen Therapy is one natural and non-invasive treatment to reduce inflammation and promote healing in a variety of conditions.

How Hyperbaric oxygen therapy reduces inflammation 

There are several ways that hyperbaric therapy can dramatically reduce inflammation. Here are three things you need to know:

  1. HBOT Speeds Up Healing
    HBOT increases the amount of oxygen in the blood and tissues, which enhances the body's ability to heal itself. Oxygen is essential for the production of energy and helps to repair damaged tissues. Additionally, oxygen helps to stimulate the production of new blood vessels, which improves circulation and reduces inflammation.

  2. HBOT Reduces Pro-Inflammatory Cytokines
    HBOT has been shown to reduce the production of pro-inflammatory cytokines, which are proteins that contribute to inflammation. Studies have found that HBOT decreases the expression of cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-alpha.

  3. HBOT Is A Natural Anti-Inflammatory Treatment
    HBOT has been found to increase the production of anti-inflammatory cytokines, such as interleukin-10. Anti-inflammatory cytokines help to suppress the immune response and reduce inflammation.


Several studies have investigated the effects of HBOT on inflammation. For example, a study published in the Journal of Biological Chemistry found that HBOT reduced inflammation in a mouse model of multiple sclerosis by decreasing the expression of pro-inflammatory cytokines and increasing the expression of anti-inflammatory cytokines. Similarly, another study published in the Journal of Trauma and Acute Care Surgery found that HBOT decreased inflammation and improved wound healing in a rat model of skin injury.

Recent research also suggests that HBOT may have a more significant impact on inflammation than previously thought. A study published in the journal Medical Gas Research found that HBOT reduced inflammation in patients with Crohn's disease, a chronic inflammatory bowel disease, and that the effect was as powerful as taking a steroid medication. The study also showed that HBOT decreased the levels of inflammatory markers, such as C-reactive protein and interleukin-6. 

Another study published in the Journal of Inflammation Research found that HBOT decreased inflammation and oxidative stress in patients with type 2 diabetes, a disease associated with significant chronic inflammation and associated with many complications including vascular disease. 

In conclusion, Inflammation is the final common dominator for many chronic medical conditions and HBOT can reverse this inflammation via increasing oxygen delivery to tissues, reducing the production of pro-inflammatory cytokines, and increasing the production of anti-inflammatory cytokines. 


  1. Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011;127 Suppl 1:131S-141S.
  2. Zhang R, et al. Hyperbaric oxygen therapy reduces inflammatory response in ischemic rat myocardium through the PI3K/Akt signaling pathway. Mediators Inflamm. 2013;2013:613782.
  3. Xu H, et al. Hyperbaric oxygen therapy suppresses NLRP3 inflammasome/caspase-1/IL-1β pathways in a rat model of multiple sclerosis. Brain Res. 2015;1627:12-20.
  4. Chen Y, et al. Hyperbaric oxygenation therapy promotes wound-healing in a murine model of hindlimb ischemia by suppressing inflammation and oxidative stress. J Trauma Acute Care Surg. 2018;84(1):142-151.
  5. Xu L, et al. Hyperbaric oxygen therapy ameliorates inflammation and oxidative stress in a rat model of Crohn's disease. Med Gas Res. 2019;9(4):190-196.
  6. Lu X, et al. Hyperbaric oxygen therapy for type 2 diabetes mellitus: a randomized, controlled clinical trial. J Inflamm Res. 2019;12:107-116.




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